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Belzutifan
CAS No. : 1672668-24-4
MCE 国际站：Belzutifan
产品活性：Belzutifan (PT2977) 是一种口服有效的，选择性 HIF-2α 抑制剂，IC50 为 9 nM。Belzutifan 作为第二代 HIF-2α 抑制剂，可提高效力并改善药代动力学特征。Belzutifan 有抑制透明细胞肾细胞癌 (ccRCC) 作用。
研究领域：Metabolic Enzyme/Protease
作用靶点：HIF/HIF Prolyl-Hydroxylase
In Vitro: Belzutifan (PT2977) potently and dose-dependently reduces mRNA levels of human cyclin D1, a target gene regulated by HIF-2α, and leads to rapid and dose-dependent reduction in EPO expression.
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