CD36,CD36抗体

产品编号HZ-1100R
英文名称CD36
中文名称CD36抗体
别 名PAS-4; Platelet glycoprotein IV; GPIV; lycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 细胞生物 免疫学 干细胞 细胞膜受体 细胞类型标志物 血管内皮细胞 内皮细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat, Dog, Pig, Horse, Bovine,
CD36,CD36抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse CD36 (45-94aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD36,CD36抗体PubMedPubMed
产品介绍background:
Endothelial Markers
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Function:
Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects.

Subunit:
Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.

CD36,CD36抗体Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes.

Post-translational modifications:
N-glycosylated and O-glycosylated with a ratio of 2:1.

DISEASE:
Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].

Similarity:
Belongs to the CD36 family.

Gene ID:
12491

Database links:
Entrez Gene: 948 Human
Entrez Gene: 12491 Mouse
Entrez Gene: 29184 Rat
Omim: 173510 Human
SwissProt: P16671 Human
SwissProt: Q08857 Mouse
SwissProt: Q07969 Rat
Unigene: 120949 Human
Unigene: 18628 Mouse
Unigene: 406799 Mouse
Unigene: 102418 Rat
Unigene: 205840 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD36属一种多功能细胞膜受体，CD36参与长链脂肪酸的吸附和调节细胞凋亡残物的清理和巨噬细胞的吞噬作用， 属于一种抗蛋白酶血小板膜表面糖蛋白。
CD36 广泛在单核细胞、巨噬细胞、内皮层细胞、血小板、红细胞前板、脂肪细胞、肌肉细胞以及乳腺内皮层细胞中有不同的表达。CD36抗原是血小板反应素的配体，两者结合后产生抑制肿瘤血管生成的效应。