Monoclonal Antibody against Human Ku, Large Subunit
产品名称： Monoclonal Antibody against Human Ku, Large Subunit
英文名称： Monoclonal Antibody against Human Ku, Large Subunit
产品编号： MMS-267R
产品价格： null
产品产地： USA
品牌商标： COVANCE
更新时间： 2024-12-10T13:14:19
使用范围：
翌圣生物科技（上海）股份有限公司
- 联系人 : 李自转
- 地址 : 上海市浦东新区天雄路166弄一号楼三层南单元
- 邮编 : 200030
- 所在区域 : 上海
- 电话 : 139****5640 点击查看
- 传真 : 点击查看
- 邮箱 : lizizhuan@yeasen.com
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| Description |  |
Monoclonal Antibody against Human Ku, Large Subunit |
| Intended Use | |
**Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. |
| Clone | |
N9C1 |
| Form | |
Ascites |
| Host | |
Mouse |
| Species Reactivity | |
Human |
| IsoType | |
IgG1 |
| Specificity | |
This monoclonal antibody was generated against a proximal sequence element binding protein isolated from human placental extract. The binding protein was later recognized to be the Ku protein. Clone N9C1 recognizes the large (84kD) subunit of the human Ku protein. This antibody is useful in identifying and removing the Ku contaminants. |
| Uses | |
This antibody is effective in immunoblotting, immunoprecipitation, immunopurification and gel-shift assays. |
| Suggested Working Dilution | |
The optimal working dilution should be determined for each specific assay condition.
|
| Notes | |
*Predicted MW = 84kDa |
| Storage | |
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. |
| References | |
Kanungo J, Empson RM, Rasmussen H. Microinjection of an antibody to the Ku protein arrests development in sea urchin embryos. Biol Bull 197(3):341-347, 1999. Wang J, Chou CH, Blankson J, Satoh M, Knuth MW, Eisenberg RA, Pisetsky DS, Reeves WH. Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. Mol Biol Rep 18:15-28, 1993. Knuth MW, Gunderson SI, Thompson NE, Strasheim LA, Burgess RP. Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human UI promoter. J Biol Chem 265:17911-17920, 1990. |
| Warranty/Conditions | |
Covance products may not be resold or modified for resale without prior written approval. |
| Rev. Date | |
1/2/2009 |